The Tubulin Code.
From: Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. kjverhey@umich.edu
Cell cycle (Georgetown, Tex.)
- Publish Date: Sep 2007
- ISSN: 1551-4005
- Volume: 6
- Issue: 17
- Pages: 2152-60
- Medium: Internet
- Language: English
- Citation (JAMA): Verhey Kristen J, Gaertig Jacek, et al. The Tubulin Code.. Cell Cycle Sep 2007;6:2152-60
Abstract
Microtubules create diverse arrays with specific cellular functions such as the mitotic spindle, cilia and bundles inside neurons. How microtubules are regulated to enable specific functions is not well understood. Recent work has shown that posttranslational modifications of the tubulin building blocks mark subpopulations of microtubules and selectively affect downstream microtubule-based functions. In this way, the tubulin modifications generate a “code” that can be read by microtubule-associated proteins in a manner analogous to how the histone code directs diverse chromatin functions. Here we review recent progress in understanding how the tubulin code is generated, maintained, and read by microtubule effectors.
Mesh Headings (Keywords): Animals, Enzymes, Humans, Microtubules, Protein Processing, Post-Translational, Tubulin
Check for Full Text / PubMed Unique Identifier (PMID): 17786050
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