Bone Marrow Derived Cells and Alternative Pathways of Oogenesis in Adult Rodents.
Cell cycle (Georgetown, Tex.)
- Publish Date: Jul 2007
- ISSN: 1551-4005
- Volume: 6
- Issue: 18
- Pages: 2306-9
- Medium: Internet
- Language: English
- Citation (JAMA): Bukovsky Antonin, Ayala Maria E, Dominguez Roberto, et al. Bone Marrow Derived Cells and Alternative Pathways of Oogenesis in Adult Rodents.. Cell Cycle Jul 2007;6:2306-9
Abstract
Oocyte generation in adult mouse ovaries by putative germ cells (PGCs) in bone marrow and peripheral blood has recently been proposed. It, however, remains unclear whether in laboratory rodents the PGCs reside in BM or the BM cells stimulate oogenesis from ovarian stem cells. We utilized immunoperoxidase staining to localize PGCs, oocytes, and BM derived cells in ovaries of adult (age 45-60 days) control and neonatally estrogenized rat females. In controls, BM derived cells accompanied emergence of PGCs from the ovarian surface epithelium (OSE) cells. The PGCs divided symmetrically, separated, and formed primordial follicles. A proportion (50%) of adult neonatally estrogenized rats lacked OSE. They exhibited occurrence of numerous BM derived cells and appearance of PGC precursors in the medulla. In juxtaposed deep ovarian cortex the emerging PGCs exhibited distinct pseudopodia and apparently migrated toward the mid cortex, where numerous primordial follicles were found. These observations indicate that BM derived cells accompany origination of PGCs from the OSE stem cells in normal adult rat females and from the medullary precursors in the adult neonatally estrogenized rats lacking OSE. An alternative origin of PGCs from the medullary region may explain why ovaries with destructed OSE are still capable of forming new primordial follicles.
Mesh Headings (Keywords): Age Factors, Animals, Bone Marrow Cells, Cell Differentiation, Cells, Cultured, Female, Oocytes, Oogenesis, Rats, Signal Transduction
Check for Full Text / PubMed Unique Identifier (PMID): 17890900
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.