Alternative Bioreactor Strategy for Probing Infection and Production.
From: Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Methods in molecular biology (Clifton, N.J.)
- Publish Date: 2007
- ISSN: 1064-3745
- Volume: 388
- Issue:
- Pages: 419-26
- Medium: Print
- Language: English
- Citation (JAMA): Hu Yu-Chen, Bentley William E, et al. Alternative Bioreactor Strategy for Probing Infection and Production.. Methods Mol. Biol. 2007;388:419-26
Abstract
Probing the baculovirus infection process is essential in optimizing the recombinant protein production. Typically, researchers monitor the infection process in the stirred tank reactor, which, however, contains a population of cells infected at different times after virus inoculation. This chapter describes a two-stage reactor system consisting of an upstream continuous stirred tank reactor and a downstream tubular reactor with segmented plug flow for probing baculovirus infection and production.
Mesh Headings (Keywords): Animals, Baculoviridae, Bioreactors, Cell Line, Spodoptera, Time Factors, beta-Galactosidase
Check for Full Text / PubMed Unique Identifier (PMID): 17951784
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