Influence of Streptozotocin Upon the Induction of Tyrosine Aminotransferase, the Content of Nad and of 5-methyl Cytosine in Rat Liver.
The International journal of biochemistry
- Publish Date: 1986
- ISSN: 0020-711X
- Volume: 18
- Issue: 9
- Pages: 821-7
- Medium: Print
- Language: English
- Citation (JAMA): Kröger H, Grätz R, Grahn H, et al. Influence of Streptozotocin Upon the Induction of Tyrosine Aminotransferase, the Content of Nad and of 5-methyl Cytosine in Rat Liver.. Int. J. Biochem. 1986;18:821-7
Abstract
The antibiotic, streptozotocin, has carcinostatic, carcinogenic, and diabetogenic properties. Moreover, it is capable of inducing the enzyme tyrosine aminotransferase in a permanent line of rat liver cells. In the present publication, the effects of streptozotocin upon the induction of tyrosine aminotransferase, NAD synthesis, and methylation of DNA in different organs were analyzed in vivo. If administered alone, streptozotocin slightly induced tyrosine aminotransferase. The induction of tyrosine aminotransferase caused by tryptophan or nicotinamide was inhibited by streptozotocin. Streptozotocin reduced the NAD content of the liver. NAD synthesis induced by tryptophan was reduced by streptozotocin, while that induced by nicotinamide was enhanced. DNA methylation in the form of 5-methyl cytosine was not influenced by streptozotocin.
Mesh Headings (Keywords): 5-Methylcytosine, Adrenalectomy, Animals, Cytosine, DNA, DNA Restriction Enzymes, Enzyme Induction, Liver, NAD, Rats, Rats, Inbred Strains, Streptozocin, Tyrosine Transaminase
Check for Full Text / PubMed Unique Identifier (PMID): 2875905
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