Topic: Animals

Journal: Journal of Medicinal Chemistry

Documents

A list of abstracts that contain a topic of "Animals" and a journal name of "Journal of Medicinal Chemistry".

• Novel Selective Inhibitors of the Zinc Plasmodial Aminopeptidase Pfa-m1 As Potential Antimalarial Agents.

  PMID: 17326615

• New Furan Side Tetracyclic Allopsoralen Derivatives: Synthesis and Photobiological Evaluation.

  PMID: 16821791

• Discovery of Potent, Orally-active, and Muscle-selective Androgen Receptor Modulators Based on an N-aryl-hydroxybicyclohydantoin Scaffold.

  PMID: 17181141

• Design, Synthesis, and Structure-activity Relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the Human A2b Adenosine Receptor.

  PMID: 16392813

• Structure-activity Relationship of 6-methylidene Penems Bearing 6,5 Bicyclic Heterocycles As Broad-spectrum Beta-lactamase Inhibitors: Evidence for 1,4-thiazepine Intermediates with C7 R Stereochemistry by Computational Methods.

  PMID: 16854068

• Benzimidazole Derivatives Bearing Substituted Biphenyls As Hepatitis C Virus Ns5b Rna-dependent Rna Polymerase Inhibitors: Structure-activity Relationship Studies and Identification of a Potent and Highly Selective Inhibitor Jtk-109.

  PMID: 16854079

• Novel 1,3-disubstituted 8-(1-benzyl-1h-pyrazol-4-yl) Xanthines: High Affinity and Selective A2b Adenosine Receptor Antagonists.

  PMID: 16759111

• Design, Synthesis, and Biological Evaluation of Phosphinopeptides Against Trypanosoma Cruzi Targeting Trypanothione Biosynthesis.

  PMID: 16392828

• Synthesis and Biological Activities of New Checkpoint Kinase 1 Inhibitors Structurally Related to Granulatimide.

  PMID: 17722905

• (+)-(2r,5s)-4-[4-cyano-3-(Trifluoromethyl)phenyl]-2,5-dimethyl-n-[6-(Trifluoromethyl)pyridin-3- Yl]piperazine-1-carboxamide (Ym580) As an Orally Potent and Peripherally Selective Nonsteroidal Androgen Receptor Antagonist.

  PMID: 16420057

• Fancy Bioisosteres: Novel Paracyclophane Derivatives As Super-affinity Dopamine D3 Receptor Antagonists.

  PMID: 16759104

• Bisphosphonate Inhibition of Phosphoglycerate Kinase: Quantitative Structure-activity Relationship and Pharmacophore Modeling Investigation.

  PMID: 17154500

• Screening for Cardiovascular Safety: a Structure-activity Approach for Guiding Lead Selection of Melanin Concentrating Hormone Receptor 1 Antagonists.

  PMID: 16570930

• Synthesis and Identification of [1,2,4]thiadiazole Derivatives As a New Series of Potent and Orally Active Dual Agonists of Peroxisome Proliferator-activated Receptors Alpha and Delta.

  PMID: 17608467

• Potential Lead for an Alzheimer Drug: a Peptide That Blocks Intermolecular Interaction and Amyloid Beta Protein-induced Cytotoxicity.

  PMID: 16884292

• Diphenyl Phosphonate Inhibitors for the Urokinase-type Plasminogen Activator: Optimization of the P4 Position.

  PMID: 16970403

• Macrocyclic Inhibitors of Beta-secretase: Functional Activity in an Animal Model.

  PMID: 17034118

• Discovery of N-[(1s,2s)-3-(4-chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(Trifluoromethyl)pyridin-2-yl]oxy}propanamide (Mk-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity.

  PMID: 17181138

• Exploration of Orally Available Calpain Inhibitors 2: Peptidyl Hemiacetal Derivatives.

  PMID: 16789748

• Discovery of Potent and Orally Available Malonyl-coa Decarboxylase Inhibitors As Cardioprotective Agents.

  PMID: 16821767

• Incorporation of an Intramolecular Hydrogen-bonding Motif in the Side Chain of 4-aminoquinolines Enhances Activity Against Drug-resistant P. Falciparum.

  PMID: 16854059

• Binding and Interaction of Dinitroanilines with Apicomplexan and Kinetoplastid Alpha-tubulin.

  PMID: 16913711

• Hybrid Antibacterials. Dna Polymerase-topoisomerase Inhibitors.

  PMID: 16480282

• Acyclic Nucleoside Analogues As Inhibitors of Plasmodium Falciparum Dutpase.

  PMID: 16821778

• Synthesis, Antifungal Activity, and Structure-activity Relationships of Coruscanone A Analogues.

  PMID: 17181171

• New Adamantane-based Spiro 1,2,4-trioxanes Orally Effective Against Rodent and Simian Malaria.

  PMID: 17266204

• New Fluorescent Adenosine A1-receptor Agonists That Allow Quantification of Ligand-receptor Interactions in Microdomains of Single Living Cells.

  PMID: 17249651

• Design, Synthesis, and in Vivo Sar of a Novel Series of Pyrazolines As Potent Selective Androgen Receptor Modulators.

  PMID: 17636947

• Synthesis and Preliminary in Vitro Investigation of Bivalent Ligands Containing Homo- and Heterodimeric Pharmacophores at Mu, Delta, and Kappa Opioid Receptors.

  PMID: 16392810

• Discovery of Antiglioma Activity of Biaryl 1,2,3,4-tetrahydroisoquinoline Derivatives and Conformationally Flexible Analogues.

  PMID: 16970409

• Rationally Designed High-affinity 2-amino-6-halopurine Heat Shock Protein 90 Inhibitors That Exhibit Potent Antitumor Activity.

  PMID: 17488003

• Synthesis, Molecular Modeling Studies, and Preliminary Pharmacological Characterization of All Possible 2-(2'-sulfonocyclopropyl)glycine Stereoisomers As Conformationally Constrained L-homocysteic Acid Analogs.

  PMID: 17725337

• Inhibition of Cytosolic Phospholipase A2alpha: Hit to Lead Optimization.

  PMID: 16392799

• Structural Insights into Human 5-lipoxygenase Inhibition: Combined Ligand-based and Target-based Approach.

  PMID: 16392803

• Synthesis and Anti-bvdv Activity of Acridones As New Potential Antiviral Agents.

  PMID: 16610805

• Novel Combretastatin Analogues Endowed with Antitumor Activity.

  PMID: 16722633

• 2-aminothiazole As a Novel Kinase Inhibitor Template. Structure-activity Relationship Studies Toward the Discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- Piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, Bms-354825) As a Potent Pan-src Kinase Inhibitor.

  PMID: 17154512

• Structure-selectivity Investigations of D2-like Receptor Ligands by Comfa and Comsia Guiding the Discovery of D3 Selective Pet Radioligands.

  PMID: 17266201

• Enaminone Amides As Novel Orally Active Gabaa Receptor Modulators.

  PMID: 17571865

• Design, Synthesis, and Estrogenic Activity of a Novel Estrogen Receptor Modulator--a Hybrid Structure of 17beta-estradiol and Vitamin E in Hippocampal Neurons.

  PMID: 17696335

• Design and Synthesis of Dual Peroxisome Proliferator-activated Receptors Gamma and Delta Agonists As Novel Euglycemic Agents with a Reduced Weight Gain Profile.

  PMID: 16970391

• Lead Compounds for Antimalarial Chemotherapy: Purine Base Analogs Discriminate Between Human and P. Falciparum 6-oxopurine Phosphoribosyltransferases.

  PMID: 17149876

• Selective Inhibition of Matrix Metalloproteinase Isozymes and in Vivo Protection Against Emphysema by Substituted Gamma-keto Carboxylic Acids.

  PMID: 16420030

• Paba/No As an Anticancer Lead: Analogue Synthesis, Structure Revision, Solution Chemistry, Reactivity Toward Glutathione, and in Vitro Activity.

  PMID: 16451080

• Selective Irreversible Inhibition of Fructose 1,6-bisphosphate Aldolase from Trypanosoma Brucei.

  PMID: 16509566

• Inhibition of Human Acetyl- and Butyrylcholinesterase by Novel Carbamates of (-)- and (+)-tetrahydrofurobenzofuran and Methanobenzodioxepine.

  PMID: 16570913

• Novel, Achiral 1,3,4-benzotriazepine Analogues of 1,4-benzodiazepine-based Cck(2) Antagonists That Display High Selectivity over Cck(1) Receptors.

  PMID: 16570921

• New Potent P-glycoprotein Inhibitors Carrying a Polycyclic Scaffold.

  PMID: 16722621

• Dissociated Nonsteroidal Glucocorticoid Receptor Modulators; Discovery of the Agonist Trigger in a Tetrahydronaphthalene-benzoxazine Series.

  PMID: 16821781

• Structural Determinants for N1/N7 Cyclization of Nicotinamide Hypoxanthine 5'-dinucleotide (Nhd+) Derivatives by Adp-ribosyl Cyclase from Aplysia Californica: Ca2+-mobilizing Activity of 8-substituted Cyclic Inosine 5'-diphosphoribose Analogues in T-lymphocytes.

  PMID: 16913705

• Design, Synthesis, and in Vitro Evaluation of Carbamate Derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones As Novel Fatty Acid Amide Hydrolase Inhibitors.

  PMID: 17665899

• Identification of New Diamine Scaffolds with Activity Against Mycobacterium Tuberculosis.

  PMID: 16722620

• Novel Potent Anticonvulsant Agent Containing a Tetrahydroisoquinoline Skeleton.

  PMID: 16942035

• Identification of Compounds with Anti-west Nile Virus Activity.

  PMID: 16539402

• Bromine- and Iodine-substituted 16alpha,17alpha-dioxolane Progestins for Breast Tumor Imaging and Radiotherapy: Synthesis and Receptor Binding Affinity.

  PMID: 16854080

• Toward Stable N4-modified Neurotensins for Nts1-receptor-targeted Tumor Imaging with 99mtc.

  PMID: 16854083

• Synthesis, Pharmacology, and Structure-activity Relationships of Novel Imidazolones and Pyrrolones As Modulators of Gabaa Receptors.

  PMID: 16539371

• Structural Investigation of the 7-chloro-3-hydroxy-1h-quinazoline-2,4-dione Scaffold to Obtain Ampa and Kainate Receptor Selective Antagonists. Synthesis, Pharmacological, and Molecular Modeling Studies.

  PMID: 17004715

• Synthesis and Biological Activity of Azido Analogues of 5,6-dimethylxanthenone-4-acetic Acid for Use in Photoaffinity Labeling.

  PMID: 17616114

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