Topic: Animals

Journal: The Journal of Pharmacology and Experimental Therapeutics

Documents

A list of abstracts that contain a topic of "Animals" and a journal name of "The Journal of Pharmacology and Experimental Therapeutics".

• An Inverse Agonist Selective for Alpha5 Subunit-containing Gabaa Receptors Enhances Cognition.

  PMID: 16326923

• Indiplon is a High-affinity Positive Allosteric Modulator with Selectivity for Alpha1 Subunit-containing Gabaa Receptors.

  PMID: 16399882

• Complete Inhibition of P-glycoprotein by Simultaneous Treatment with a Distinct Class of Modulators and the Uic2 Monoclonal Antibody.

  PMID: 17050779

• Presynaptic Delta Opioid Receptors Regulate Ethanol Actions in Central Amygdala.

  PMID: 17114568

• Constitutive Activity and Inverse Agonism at the M2 Muscarinic Acetylcholine Receptor.

  PMID: 16188951

• Pharmacological and Electrophysiological Characterization of Store-operated Currents and Capacitative Ca(2+) Entry in Vascular Smooth Muscle Cells.

  PMID: 16415091

• Interaction of Riluzole with the Closed Inactivated State of Kv4.3 Channels.

  PMID: 16815868

• Effects of Anesthetics on Mutant N-methyl-d-aspartate Receptors Expressed in Xenopus Oocytes.

  PMID: 16622040

• Modeling Drug- and System-related Changes in Body Temperature: Application to Clomethiazole-induced Hypothermia, Long-lasting Tolerance Development, and Circadian Rhythm in Rats.

  PMID: 16339393

• The Contribution of Intestinal Udp-glucuronosyltransferases in Modulating 7-ethyl-10-hydroxy-camptothecin (Sn-38)-induced Gastrointestinal Toxicity in Rats.

  PMID: 17003228

• Soraprazan: Setting New Standards in Inhibition of Gastric Acid Secretion.

  PMID: 17369284

• Gambierol Acts As a Functional Antagonist of Neurotoxin Site 5 on Voltage-gated Sodium Channels in Cerebellar Granule Neurons.

  PMID: 17609421

• Cj-023,423, a Novel, Potent and Selective Prostaglandin Ep4 Receptor Antagonist with Antihyperalgesic Properties.

  PMID: 17495127

• The Novel, Orally Active, Delta Opioid Rwj-394674 is Biotransformed to the Potent Mu Opioid Rwj-413216.

  PMID: 16766719

• A Single Intraperitoneal Dose of Carbon Monoxide-saturated Ringer's Lactate Solution Ameliorates Postoperative Ileus in Mice.

  PMID: 16943253

• Hyperforin Blocks Neutrophil Activation of Matrix Metalloproteinase-9, Motility and Recruitment, and Restrains Inflammation-triggered Angiogenesis and Lung Fibrosis.

  PMID: 17289834

• The Fatty Acid Amide Hydrolase Inhibitor Urb597 (Cyclohexylcarbamic Acid 3'-carbamoylbiphenyl-3-yl Ester) Reduces Neuropathic Pain After Oral Administration in Mice.

  PMID: 17412883

• Neuroproteomics of the Synapse and Drug Addiction.

  PMID: 16644901

• Low Sensitivity of the Positron Emission Tomography Ligand [11c]diprenorphine to Agonist Opiates.

  PMID: 17488881

• A Novel Azaindolizinone Derivative Zset1446 (Spiro[Imidazo[1,2-a]pyridine-3,2-indan]-2(3h)-one) Improves Methamphetamine-induced Impairment of Recognition Memory in Mice by Activating Extracellular Signal-regulated Kinase 1/2.

  PMID: 17090702

• The in Vivo Contributions of Task-1-containing Channels to the Actions of Inhalation Anesthetics, the Alpha(2) Adrenergic Sedative Dexmedetomidine, and Cannabinoid Agonists.

  PMID: 16397088

• Augmentation of Cav3.2 T-type Calcium Channel Activity by Camp-dependent Protein Kinase A.

  PMID: 16569752

• Chronic Matrix Metalloproteinase Inhibition Following Myocardial Infarction in Mice: Differential Effects on Short and Long-term Survival.

  PMID: 16757539

• Effect of Duration and Pattern of Chronic Ethanol Exposure on Tolerance to the Discriminative Stimulus Effects of Ethanol in C57bl/6j Mice.

  PMID: 16914560

• Desoxyrhaponticin (3,5-dihydroxy-4'-methoxystilbene 3-o-beta-d-glucoside) Inhibits Glucose Uptake in the Intestine and Kidney: In Vitro and in Vivo Studies.

  PMID: 17038511

• Cardiac Glycosides As Novel Inhibitors of Human Ether-a-go-go-related Gene Channel Trafficking.

  PMID: 17095614

• Pharmacokinetics and Pharmacodynamics of Gamma-hydroxybutyric Acid During Tolerance in Rats: Effects on Extracellular Dopamine.

  PMID: 17138862

• Chronic Nicotine Differentially Regulates Alpha6- and Beta3-containing Nicotinic Cholinergic Receptors in Rat Brain.

  PMID: 17446303

• A Novel Oral Indoline-sulfonamide Agent, N-[1-(4-methoxybenzenesulfonyl)-2,3-dihydro-1h-indol-7-yl]-isonicotinamide (J30), Exhibits Potent Activity Against Human Cancer Cells in Vitro and in Vivo Through the Disruption of Microtubule.

  PMID: 17660383

• Effects of Rgh-237 [N-{4-[4-(3-aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an Orally Active, Selective Dopamine D(3) Receptor Partial Agonist in Animal Models of Cocaine Abuse.

  PMID: 17170312

• The Role of Protein Kinase C Isoforms in Modulating Injury and Repair of the Intestinal Barrier.

  PMID: 16002462

• Modulation of Brainstem Opiate Analgesia in the Rat by Sigma 1 Receptors: a Microinjection Study.

  PMID: 17545312

• Discovery of Pyrrolo[2,3-b]pyrazines Derivatives As Submicromolar Affinity Activators of Wild Type, G551d, and F508del Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels.

  PMID: 16829626

• Stimulation of Ca2+-gated Cl- Currents by the Calcium-dependent K+ Channel Modulators Ns1619 [1,3-dihydro-1-[2-hydroxy-5-(Trifluoromethyl)phenyl]-5-(Trifluoromethyl)-2h-benzimidazol-2-one] and Isopimaric Acid.

  PMID: 17347326

• The Metabolism and Toxicity of Furosemide in the Wistar Rat and Cd-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore.

  PMID: 17556636

• Neuronal Nitric-oxide Synthase Inhibition Facilitates Adrenergic Neurotransmission in Rat Mesenteric Resistance Arteries.

  PMID: 16236814

• Ava[L-pro9,n-meleu10] Substance P(7-11) (Gr 73632) and Sar9, Met(O2)11 Increase Distention-induced Peristalsis Through Activation of Neurokinin-1 Receptors on Smooth Muscle and Interstitial Cells of Cajal.

  PMID: 16330493

• Pleiotropic Effects of the Beta-adrenoceptor Blocker Carvedilol on Calcium Regulation During Oxidative Stress-induced Apoptosis in Cardiomyocytes.

  PMID: 16611853

• Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a Potent, Broad-spectrum State-dependent Sodium Channel Blocker for Treating Pain States.

  PMID: 16728593

• Effect of Natriuretic Peptide Receptor Antagonist on Lipopolysaccharide-induced Fever in Rats: is Natriuretic Peptide an Endogenous Antipyretic?

  PMID: 16751254

• Effects of the Protein Kinase Inhibitor, Imatinib Mesylate, on Epithelial/Mesenchymal Phenotypes: Implications for Treatment of Fibrotic Diseases.

  PMID: 17218487

• Pharmacological Activation of Rapid Delayed Rectifier Potassium Current Suppresses Bradycardia-induced Triggered Activity in the Isolated Guinea Pig Heart.

  PMID: 17325228

• M2 and M3 Muscarinic Receptor Activation of Urinary Bladder Contractile Signal Transduction. I. Normal Rat Bladder.

  PMID: 16243961

• Endothelial Targeting of High-affinity Multivalent Polymer Nanocarriers Directed to Intercellular Adhesion Molecule 1.

  PMID: 16505161

• Effects of Combined Dopamine and Serotonin Transporter Inhibitors on Cocaine Self-administration in Rhesus Monkeys.

  PMID: 17105829

• Mesenteric Vasoconstriction and Hindquarters Vasodilatation Accompany the Pressor Actions of Exendin-4 in Conscious Rats.

  PMID: 16221740

• Delta Opioid Receptors Stimulate Akt-dependent Phosphorylation of C-jun in T Cells.

  PMID: 16249373

• Maternal Separation and Handling Affects Cocaine Self-administration in Both the Treated Pups As Adults and the Dams.

  PMID: 16517692

• Differentiation of Arrhythmia Risk of the Antibacterials Moxifloxacin, Erythromycin, and Telithromycin Based on Analysis of Monophasic Action Potential Duration Alternans and Cardiac Instability.

  PMID: 16614168

• Modulation of Pro- and Antiapoptotic Molecules in Double-positive (Cd4+cd8+) Thymocytes Following Dexamethasone Treatment.

  PMID: 16914556

• Fetal and Neonatal Nicotine Exposure Differentially Regulates Vascular Contractility in Adult Male and Female Offspring.

  PMID: 17068201

• Sr 16435 [1-(1-(Bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a Novel Mixed Nociceptin/Orphanin Fq/Mu-opioid Receptor Partial Agonist: Analgesic and Rewarding Properties in Mice.

  PMID: 17132815

• Anti-inflammatory Mechanisms of Isoflavone Metabolites in Lipopolysaccharide-stimulated Microglial Cells.

  PMID: 17194798

• A Comparison Between the Cardiovascular Actions of Urocortin 1 and Urocortin 2 (Stresscopin-related Peptide) in Conscious Rats.

  PMID: 17237259

• (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic Acid ((2r,3s)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (Vx-765), an Orally Available Selective Interleukin (Il)-converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-inflammatory Activities by Inhibiting the Release of Il-1beta and Il-18.

  PMID: 17289835

• Nateglinide and Mitiglinide, but Not Sulfonylureas, Induce Insulin Secretion Through a Mechanism Mediated by Calcium Release from Endoplasmic Reticulum.

  PMID: 17409272

• Regulation of Alpha1-adrenoceptor-mediated Contractions of the Uterine Artery by Protein Kinase C: Role of the Thick- and Thin-filament Regulatory Pathways.

  PMID: 17562849

• Marked Strain Differences in the Pharmacokinetics of an Alpha4beta1 Integrin Antagonist, 4-[1-[3-chloro-4-[N-(2-methylphenyl)-ureido]phenylacetyl]-(4s)-fluoro-(2s)-pyrrolidine-2-yl]-methoxybenzoic Acid (D01-4582), in Sprague-dawley Rats Are Associated with Albumin Genetic Polymorphism.

  PMID: 17038508

• Hypoxic Induction of Receptor Activity-modifying Protein 2 Alters Regulation of Pulmonary Endothelin-1 by Adrenomedullin: Induction Under Normoxia Versus Inhibition Under Hypoxia.

  PMID: 17251392

• Qt Prolongation Modifies Dynamic Restitution and Hysteresis of the Beat-to-beat Qt-tq Interval Relationship During Normal Sinus Rhythm Under Varying States of Repolarization.

  PMID: 16204470

• Preventive and Therapeutic Potential of P38 Alpha-selective Mitogen-activated Protein Kinase Inhibitor in Nonobese Diabetic Mice with Type 1 Diabetes.

  PMID: 16603672

• Biotransformation of Glyceryl Trinitrate by Rat Hepatic Microsomal Glutathione S-transferase 1.

  PMID: 16720755

• Translocation of At1- and At2-receptors by Higher Concentrations of Angiotensin Ii in the Smooth Muscle Cells of Rat Internal Anal Sphincter.

  PMID: 16985169

• Marked Insulin Resistance in Obese Spontaneously Hypertensive Rat Adipocytes is Ameliorated by in Vivo but Not in Vitro Treatment with Moxonidine.

  PMID: 17095615

• Inhibition of Lipopolysaccharide-induced Prostaglandin E2 Production and Inflammation by the Na+/H+ Exchanger Inhibitors.

  PMID: 17237260

• Simvastatin Improves Diabetes-induced Coronary Endothelial Dysfunction.

  PMID: 16849625

• Modulation of Contractile Function Through Neuropeptide Y Receptors During Development of Cardiomyocyte Hypertrophy.

  PMID: 16973886

• The Prevention of Colitis by E Prostanoid Receptor 4 Agonist Through Enhancement of Epithelium Survival and Regeneration.

  PMID: 17008451

• Muscarinic M2 Receptors Directly Activate Gq/11 and Gs G-proteins.

  PMID: 17065363

• Cocaine Esterase: Interactions with Cocaine and Immune Responses in Mice.

  PMID: 17114567

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