Topic: Binding Sites

Journal: Journal of Medicinal Chemistry

Documents

A list of abstracts that contain a topic of "Binding Sites" and a journal name of "Journal of Medicinal Chemistry".

• Flipped Out: Structure-guided Design of Selective Pyrazolylpyrrole Erk Inhibitors.

  PMID: 17300186

• Inspection of the Binding Sites of Proteinase3 for the Design of a Highly Specific Substrate.

  PMID: 16480262

• Knowledge-based Design of Target-focused Libraries Using Protein-ligand Interaction Constraints.

  PMID: 16420036

• Design, Synthesis, and Biological Evaluation of 3,4-diarylmaleimides As Angiogenesis Inhibitors.

  PMID: 16480264

• Pharmacological Characteristics and Binding Modes of Caracurine V Analogues and Related Compounds at the Neuronal Alpha7 Nicotinic Acetylcholine Receptor.

  PMID: 17722904

• Carbonic Anhydrase Activators. Activation of Isoforms I, Ii, Iv, Va, Vii, and Xiv with L- and D-phenylalanine and Crystallographic Analysis of Their Adducts with Isozyme Ii: Stereospecific Recognition Within the Active Site of an Enzyme and Its Consequences for the Drug Design.

  PMID: 16686544

• Novel 3-o-glycosyl-3-demethylthiocolchicines As Ligands for Glycine and Gamma-aminobutyric Acid Receptors.

  PMID: 17411024

• Hiv-1 Protease Mutations and Inhibitor Modifications Monitored on a Series of Complexes. Structural Basis for the Effect of the A71v Mutation on the Active Site.

  PMID: 16970402

• Profile and Molecular Modeling of 3-(Indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H-pyrrole-2,5-dione (1) As a Highly Selective Vegf-r2/3 Inhibitor.

  PMID: 17149885

• Docking and Three-dimensional Quantitative Structure-activity Relationship (3d Qsar) Analyses of Nonsteroidal Progesterone Receptor Ligands.

  PMID: 16821785

• Relationship of Potency and Resilience to Drug Resistant Mutations for Gw420867x Revealed by Crystal Structures of Inhibitor Complexes for Wild-type, Leu100ile, Lys101glu, and Tyr188cys Mutant Hiv-1 Reverse Transcriptases.

  PMID: 17441703

• Biosensor-based Kinetic Characterization of the Interaction Between Hiv-1 Reverse Transcriptase and Non-nucleoside Inhibitors.

  PMID: 16610780

• Characterization of the Histamine H4 Receptor Binding Site. Part 1. Synthesis and Pharmacological Evaluation of Dibenzodiazepine Derivatives.

  PMID: 16854056

• Insight Through Molecular Mechanics Poisson-boltzmann Surface Area Calculations into the Binding Affinity of Triclosan and Three Analogues for Fabi, the E. Coli Enoyl Reductase.

  PMID: 16854062

• Transient Pockets on Protein Surfaces Involved in Protein-protein Interaction.

  PMID: 17602601

• Discovery of Protein Phosphatase 2c Inhibitors by Virtual Screening.

  PMID: 16509582

• Dynamic Pharmacophore Model Optimization: Identification of Novel Hiv-1 Integrase Inhibitors.

  PMID: 16509584

• Conformationally Constrained Analogues of Diacylglycerol (Dag). 28. Dag-dioxolanones Reveal a New Additional Interaction Site in the C1b Domain of Pkc Delta.

  PMID: 17591763

• 7'-substituted Benzothiazolothio- and Pyridinothiazolothio-purines As Potent Heat Shock Protein 90 Inhibitors.

  PMID: 16913725

• Structure-based Optimization of Protein Tyrosine Phosphatase 1b Inhibitors: from the Active Site to the Second Phosphotyrosine Binding Site.

  PMID: 17705360

• Design and Synthesis of Photoaffinity-labeling Ligands of the L-prolyl-l-leucylglycinamide Binding Site Involved in the Allosteric Modulation of the Dopamine Receptor.

  PMID: 16392815

• Discovery of a Novel Family of Sars-cov Protease Inhibitors by Virtual Screening and 3d-qsar Studies.

  PMID: 16759091

• Modeling the Ligand-receptor Interaction for a Series of Inhibitors of the Capsid Protein of Enterovirus 71 Using Several Three-dimensional Quantitative Structure-activity Relationship Techniques.

  PMID: 16854057

• Synthesis and Anti-hiv Activity of D- and L-thietanose Nucleosides.

  PMID: 16509580

• Progressive Docking: a Hybrid Qsar/Docking Approach for Accelerating in Silico High Throughput Screening.

  PMID: 17149875

• Identification of Novel Parasitic Cysteine Protease Inhibitors by Use of Virtual Screening. 2. The Available Chemical Directory.

  PMID: 16509575

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