Topic: Humans

Journal: Journal of Medicinal Chemistry

Documents

A list of abstracts that contain a topic of "Humans" and a journal name of "Journal of Medicinal Chemistry".

• Synthesis and Biological Studies of a New Series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines As Human A3 Adenosine Receptor Antagonists. Influence of the Heteroaryl Substituent on Binding Affinity and Molecular Modeling Investigations.

  PMID: 16509587

• Quinol-4-ones As Steroid A-ring Mimetics in Nonsteroidal Dissociated Glucocorticoid Agonists.

  PMID: 17181172

• Synthetic Inhibitors of Cytochrome P-450 2a6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization.

  PMID: 17125252

• Synthesis of Anthranylaldoxime Derivatives As Estrogen Receptor Ligands and Computational Prediction of Binding Modes.

  PMID: 16884312

• Quick Assembly of 1,4-diphenyltriazoles As Probes Targeting Beta-amyloid Aggregates in Alzheimer's Disease.

  PMID: 17569520

• Immuno-suppressive Effect of Blocking the Cd28 Signaling Pathway in T-cells by an Active Component of Echinacea Found by a Novel Pharmaceutical Screening Method.

  PMID: 16539370

• (2s,3s)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-n,n-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a Selective Alpha-amino Amide Dipeptidyl Peptidase Iv Inhibitor for the Treatment of Type 2 Diabetes.

  PMID: 16759103

• 2-amino and 2'-aminocombretastatin Derivatives As Potent Antimitotic Agents.

  PMID: 17034147

• Synthesis and Biological Evaluation of Novel 1-deoxy-1-[6-[((Hetero)arylcarbonyl)hydrazino]- 9h-purin-9-yl]-n-ethyl-beta-d-ribofuranuronamide Derivatives As Useful Templates for the Development of A2b Adenosine Receptor Agonists.

  PMID: 17228880

• New 2-alkylidene 1alpha,25-dihydroxy-19-norvitamin D3 Analogues of High Intestinal Activity: Synthesis and Biological Evaluation of 2-(3'-alkoxypropylidene) and 2-(3'-hydroxypropylidene) Derivatives.

  PMID: 16686534

• New Arylthioindoles: Potent Inhibitors of Tubulin Polymerization. 2. Structure-activity Relationships and Molecular Modeling Studies.

  PMID: 16451061

• 1-(4-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) Analogues: a Promising Class of Monoamine Uptake Inhibitors.

  PMID: 16480278

• Doxazolidine Induction of Apoptosis by a Topoisomerase Ii Independent Mechanism.

  PMID: 17696516

• Fk506-binding Protein Ligands: Structure-based Design, Synthesis, and Neurotrophic/Neuroprotective Properties of Substituted 5,5-dimethyl-2-(4-thiazolidine)carboxylates.

  PMID: 16821768

• Is the Sigma2 Receptor a Histone Binding Protein?

  PMID: 16821775

• 1-aminomethylbenzocycloalkanes: Conformationally Restricted Hallucinogenic Phenethylamine Analogues As Functionally Selective 5-ht2a Receptor Agonists.

  PMID: 16970404

• Structure-activity Relationship Studies of Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4h-chromene-3-carboxylate (Ha 14-1), an Antagonist for Antiapoptotic Bcl-2 Proteins to Overcome Drug Resistance in Cancer.

  PMID: 17181155

• 1,4-benzodiazepines As Inhibitors of Respiratory Syncytial Virus. The Identification of a Clinical Candidate.

  PMID: 17341059

• Unsaturated Cationic Ortho Esters for Endosome Permeation in Gene Delivery.

  PMID: 17691717

• Synthesis and Cytotoxicity of Leinamycin Antibiotic Analogues.

  PMID: 16942037

• Isolation, Structure Elucidation, Total Synthesis, and Evaluation of New Natural and Synthetic Ceramides on Human Sk-mel-1 Melanoma Cells.

  PMID: 16970407

• Synthesis of Thieno[2,3-b]pyridinones Acting As Cytoprotectants and As Inhibitors of [3h]glycine Binding to the N-methyl-d-aspartate (Nmda) Receptor.

  PMID: 16451052

• Discovery of [4-amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- Methoxyphenyl)methanone (R547), a Potent and Selective Cyclin-dependent Kinase Inhibitor with Significant in Vivo Antitumor Activity.

  PMID: 17064073

• Design and Synthesis of N-(3,3-diphenylpropenyl)alkanamides As a Novel Class of High-affinity Mt2-selective Melatonin Receptor Ligands.

  PMID: 17149869

• A New Class of Blockers of the Voltage-gated Potassium Channel Kv1.3 Via Modification of the 4- or 7-position of Khellinone.

  PMID: 16480279

• Synthesis and Sar Studies of 2-oxoquinoline Derivatives As Cb2 Receptor Inverse Agonists.

  PMID: 16539390

• Comparison Between 5,10,15,20-tetraaryl- and 5,15-diarylporphyrins As Photosensitizers: Synthesis, Photodynamic Activity, and Quantitative Structure-activity Relationship Modeling.

  PMID: 16722648

• Aminopyridine-based C-jun N-terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-kinase Activity.

  PMID: 16759099

• Synthesis, Radiosynthesis, and Biological Evaluation of Carbon-11 Labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: Candidate Radioligands for in Vivo Imaging of the Serotonin Transporter with Positron Emission Tomography.

  PMID: 17154506

• Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines As Selective Inhibitors of Aurora B Kinase.

  PMID: 17373783

• Orally Bioavailable Potent Soluble Epoxide Hydrolase Inhibitors.

  PMID: 17616115

• Discovery and Optimization of Anthranilic Acid Sulfonamides As Inhibitors of Methionine Aminopeptidase-2: a Structural Basis for the Reduction of Albumin Binding.

  PMID: 16789740

• Structure-activity Relationships of a Novel Series of Urotensin Ii Analogues: Identification of a Urotensin Ii Antagonist.

  PMID: 17125276

• Discovery of Benzylidenebenzofuran-3(2h)-one (Aurones) As Inhibitors of Tyrosinase Derived from Human Melanocytes.

  PMID: 16392817

• Tumor-cell-targeted Methionine-enkephalin Analogues Containing Unnatural Amino Acids: Design, Synthesis, and in Vitro Antitumor Activity.

  PMID: 16722632

• Transplatin is Cytotoxic when Photoactivated: Enhanced Formation of Dna Cross-links.

  PMID: 17181161

• Atropisomeric 3-(Beta-hydroxyethyl)-4-arylquinolin-2-ones As Maxi-k Potassium Channel Openers.

  PMID: 17274609

• Discovery of 3-piperidinyl-1-cyclopentanecarboxamide As a Novel Scaffold for Highly Potent Cc Chemokine Receptor 2 Antagonists.

  PMID: 17461566

• Discovery of Novel Antitumor Antimitotic Agents That Also Reverse Tumor Resistance.

  PMID: 17567121

• Reaction of Zn7metallothionein with Cis- and Trans-[Pt(N-donor)2cl2] Anticancer Complexes: Trans-pt(Ii) Complexes Retain Their N-donor Ligands.

  PMID: 17665893

• 2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide Substructures As a Novel Series of Rationally Designed Histone Deacetylase Inhibitors.

  PMID: 17691763

• Design, Synthesis, and Binding Affinities of Potential Positron Emission Tomography (Pet) Ligands for Visualization of Brain Dopamine D3 Receptors.

  PMID: 16392820

• Novel Structural Features of Cdk Inhibition Revealed by an Ab Initio Computational Method Combined with Dynamic Simulations.

  PMID: 16913703

• 7-aroyl-aminoindoline-1-sulfonamides As a Novel Class of Potent Antitubulin Agents.

  PMID: 17154496

• Synthesis and Biological Evaluation of 6-(Alkyn-1-yl)furo[2,3-d]pyrimidin-2(3h)-one Base and Nucleoside Derivatives.

  PMID: 16392824

• Selective Inhibition of Carboxylesterases by Isatins, Indole-2,3-diones.

  PMID: 17378546

• Synthesis and Antiviral and Cytostatic Evaluations of the New C-5 Substituted Pyrimidine and Furo[2,3-d]pyrimidine 4',5'-didehydro-l-ascorbic Acid Derivatives.

  PMID: 17672445

• In Silico Human and Rat Vss Quantitative Structure-activity Relationship Models.

  PMID: 16539383

• Second Generation, Orally Active, Antimalarial, Artemisinin-derived Trioxane Dimers with High Stability, Efficacy, and Anticancer Activity.

  PMID: 16640333

• Synthesis, Antitumor Activity, and Mechanism of Action of Benzo[A]pyrano[3,2-h]acridin-7-one Analogues of Acronycine.

  PMID: 16722658

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